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Proper Dosing and
Frontloading using
the Principles of Half-Life’s
I’ve decided to write this article in regards to a great
post made by Got Gear. He simply stated that at no time during a cycle will your
test levels reach above 500mg a week if you’re taking 500mg a week of test
enanthate. This is so very true and a lot more detailed than you probably think.
This is what we base our dosages on since the onset and peak of most AAS is/are
not established. The definition of half-life in regards to biology and
pharmacology is simply the time required by the body, tissue, or organ to
metabolize or inactivate half the amount of a substance taken in (Taber’s
Cyclopedic Medical Dictionary). These principles are used for all medications,
not just AAS. I’m going to break this down to the simplest form I can so bare
with me because it may get a little confusing.
The key thing to remember when it comes to half-life’s is that they will
always be reduced by half of what’s remaining on a proportional and timely
basis.
I’m going to use Testosterone Cypionate as my example in this demonstration
since it is a commonly used AAS for beginners and pros alike.
Testosterone Cypionate half-life is 8 days (Davis’s Drug Guide for Nurses 9th
Ed.)
500mg Test Cyp every 8 days
Day 1 – 500mg (remember that the bioavailability at this point is 0 because it
takes 8 days to metabolize 250mg, and this will be true for every dose that
follows)
Day 9 – 500mg (remember what was stated on day 1), so at this point you have
250mg remaining in the body from day 1 because your body has used 250mg over the
past 8 days)
Day 17 – 500mg, at this point you have 250 from Day 9 and 125 from day 1
(don’t confuse yourself here, the body does not process 250mg every 8 days, it
simply reduces the remaining by half every 8 days)
Day 25 – 500mg, at this point you have 250mg from Day 17, 125 from Day 9, and
now just 62.5 remaining from day 1
Day 33 – 500mg, at this point you have 250mg from Day 25, 125 from Day 17,
62.5 from Day 9, and 31.7 from day 1.
The easy way to keep going on with this formula is to take the smallest number
(31.7 in this case) and reduce it by half, then add it to your existing numbers
for the total, and then repeat.
The total looks like this:
The first 8 days your body will metabolize 250mg
The second 8 days your body will metabolize half of the remaining 250 (125) and
half of the 500 (250) administered on day 9 for a total of 375.
The third 8 days your body will metabolize 250, 125, and 62.5 for a total of
437.5. This is one reason it takes a couple of weeks to start noticing the
effects of this drug.
To keep figuring out the bioavailability just keep reducing your smallest number
by half and adding it to the total as described earlier.
Here is a chart demonstrating the bioavailability and how long it takes to even
reach that 500mg per 8 day mark. For this demonstration we will use 8 days for 1
wk.
Wk 1 – 250mg
Wk 2 – 375mg
Wk 3 – 437.5mg
Wk 4 – 469.2mg
Wk 5 – 485mg
Wk 6 – 492.9mg
Wk 7 – 496.8mg
Wk 8 – 498.7mg
And so on….
So what does all this mean? Well for one it brings up a very important issue of
frontloading. To frontload, you simply double your weekly dose just for that
first week. It would look like this:
Wk 1 – 1000mg Cyp
Wk 2 – 500mg Cyp
Wk 3 – 500mg Cyp
And continue on at the normal 500mg/wk
The way this works is simple, during week 1 your body will metabolize 500mg of
the first dose leaving you with 500 remaining. The second week your body will
metabolize 250mg from the first dose and also 250 from the second dose for a
total of 500. Now do you see how beneficial frontloading really is? You will
stay constant at 500mg/wk throughout your cycle instead of tapering up by not
frontloading.
All that has been described in this post is hypothetically based on the
principles of half-life’s. Nevertheless, this should give you a general idea
of how much your body is using in any one given week. This holds true for every
AAS and medication there is, after all that’s what medication administration
is based on so don’t argue with me about this, argue with science and the
millions of doctors who actually get paid to come up with this stuff.
Also, on a side note, I’ve noticed quite a few boards that vary on half-lifes
for certain AAS such as Cyp, most state the half-life as being around 10 days.
I’m in no way saying this is wrong but I tend to get and base as much
information as possible on medical articles and websites. I have found the
half-life of cyp to be 8 days both in a nursing book and also on drug.com. The
only catch to this is that some, in fact most AAS are not evaluated, published,
or even talked about in the medical field so your on your own on that one.
Peace,
written by Superduty at worldclassbodybuilding.com
Feel free to discuss this article here.
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