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Orabolin
Pharmaceutical Name: Ethylestrenol
Chemical structure: 19-Nor-17alpha-pregn-4-en-17-ol,
17alpha-ethly-estr-4-en-17b-ol
Molecular weight of base: 288.4722
Active Life: 12-16 hours
Anabolic/Androgenic Ratio: 200-400/20-400
Ethylestrenol is an oral steroid derived from nandrolone. It was first
manufactured as an oral alternative to nandrolone decanoate, however as will
be described, this intention was not necessarily fulfilled. Similar to other
nandrolone derived steroids ethylestrenol offers mild anabolic properties with
little in the way of androgenic side effects or benefits. For this reason it
is often looked upon as an extremely mild steroid that will not provide major
increases in muscle mass or strength, but will also not subject its users to
severe side effects for the most part.
Ethylestrenol is similar in its chemical structure to the anabolic steroid
norethandrolone/Nilevar. The primary difference between them is that while
norethandrolone has a 3-keto group attached, ethylestrenol does not. This
3-keto group does seemingly make norethandrolone more anabolic then
ethylestrenol as it is responsible for strengthening the ability of the
compound to bond with the androgen receptor. In fact there is a limited amount
of evidence that suggests that the anabolic effect that ethylestrenol does
exhibit is actually produced when a 3-keto group is produced and the drug is
essentially converted to norethandrolone in the system of the user (1).
However more research on the subject needs to be conducted before this
conversion could be proven to actually exist.
Since ethylestrenol is an oral steroid, to remain active after when
administered by swallowing the compound, it has undergone 17 alpha alkylation.
Like other oral steroids, while this procedure allows for some steroids to be
taken orally it can also lead to hepatoxicity when used in large enough doses
and/or for a long enough duration.
In essence ethylestrenol is a low risk anabolic steroid in terms of negative
side effects. The trade off is that it will only deliver low to moderate gains
in muscle mass and strength for users, even at large doses. Some users will
find that this ratio of risk and reward is fine but for those that are looking
for dramatic results, they will likely be left wanting for more.
Use and Dosing of Orabolin
Due to ethylestrenol being a 17 alpha alkylated steroid, the cycle duration
for this steroid should be kept relatively short. Four to six weeks should be
plenty of time to reap the benefits of the compound while also limiting any
risk of significant hepatoxicity. Of course cycles lasting longer then six
weeks are possible with ethylestrenol depending on how the individual user
reacts to 17 alpha alkylated compounds, but if a user desires to run this or
any other 17 alpha alkylated steroid he or she should have his or her liver
values monitored consistently to negate any risk of liver toxicity.
In terms of doses required, twenty to fifty milligrams per day should be
enough for the majority of male users to see good results from ethylestrenol.
For females, doses ranging from anywhere from ten to twenty milligrams per day
should be adequate to produce gains in muscle mass and strength. Of course
like with all anabolic steroids users should use caution and start out using
doses on the lower end of the range and increase as needed.
For dosing frequency, because the active life of the drug is approximately
twelve to sixteen hours in length users should be fine to administer two
evenly divided doses throughout the day. This should be adequate to have
enough of the compound circulating in the system of the user to provide
benefits over the course of twenty-four hours.
Due to ethylestrenol being derived from nandrolone, it suppresses the natural
testosterone production of users rather rapidly and significantly. For this
reason it is advisable that male users also run testosterone while
administering ethylestrenol. Without exogenous testosterone being administered
it is likely that the user will suffer from a diminished sex drive and
possibly sexual dysfunction. With testosterone the risk of suffering such
conditions should be minimized.
Risks and Side Effects while using Orabolin
Due to the low androgenic and anabolic nature of the drug, ethylestrenol does
not lead to many significant negative side effects in users. Indeed it
actually has exhibited positive effects in users in terms of fighting off some
diseases and generally raising the immune system (2). However this does not
mean that the drug is absolutely risk free.
As noted with nearly all other 17 alpha alkylated steroids, hepatoxicity is a
concern with ethylestrenol. Elevated liver values will undoubtedly occur while
running this drug for any significant amount of time. However as indicated
earlier, the burden placed on the liver should be minimal and not severe as
long as doses remain moderate and the duration of the cycle is not overly
extensive. Caution should also be used if taking two or more 17 alpha
alkylated steroids concurrently.
Androgenic and estrogenic side effects should be nearly non-existent with
ethylestrenol. Much like nandrolone decanoate and other nandrolone derived
steroids, the low rate of aromatization will negate much of the possibility of
estrogenic side effects developing in male users. However ethylestrenol can
cause progesterone-like effects in some users. Commonly reported sides effects
associated with nandrolone derived steroids such as ethylestrenol are symptoms
like acne/oily skin, insomnia, diarrhea, and nausea. These of course are
coupled with the common side effects most often associated with anabolic
steroids including testicular atrophy, gynecomastia (including lactation in
some cases), and sexual dysfunction.
The described negative side effects will likely be far less severe with
ethylestrenol then most other nandrolone derived steroids simply due to the
lower total amount of the steroid that can be ingested. However if these
symptoms do develop several options exist to help combat them. These will be
slightly different then those used for estrogenic side effects since
nandrolone is a progestinic anabolic steroid (3, 4). Using compounds such as
bromcriptine, cabergoline and/or vitamin b6 have all been shown and reported
to help lower prolactin levels. The drug femera (letrozole) is also effective
for use with nandrolone as it will regulate the progesterone and estrogen
receptors in the body, therefore preventing some of the negative side effects
associated with the compound.
Ethylestrenol has also been shown to have relatively mild effects on females
in the limited research that exists (5). Virilizing symptoms did not appear to
be a significant problem with this drug when doses were kept within a
relatively moderate range. Only the usual side effects such as an irregular
menstrual cycle (5, 6) were noted. It appears that ethylestrenol is a
relatively safe compound for use by females.
References
1. Ward R, Lawson AM, Schackleton CLH. Metabolism of anabolic
steroid drugs in man and the marmoset monkey (callithrix jacchus) - Nilevar
and orabolin. J Steroid Biochem. 1977 (8): 1057-63.
2. Schuurs AH, Verheul HA, Schot LP. Experimental work with anabolics in
autoimmunity models. Acta Endocrinol Suppl (Copenh). 1985;271:97-108.
3. Hochberg RB, Hoyte RM, Rosner W., E-17
alpha-(2-[125I]iodovinyl)-19-nortestosterone: the synthesis of a
gamma-emitting ligand for the progesterone receptor., Endocrinology 1985
Dec;117(6):2550-2
4.Sattler FR, Schroeder ET, Dube MP, Jaque SV, Martinez C, Blanche PJ, Azen S,
Krauss RM. Metabolic effects of nandrolone decanoate and resistance training
in men with HIV. Am J Physiol Endocrinol Metab. 2002 Dec;283(6): E1214-22
5. Bolch OH Jr, Warren JC. Induction of premature menstruation with anabolic
steroids. Am J Obstet Gynecol. 1973 Sep 1;117(1):121-5.
6. Selye H, Tache Y, Szabo S. Interruption of pregnancy by various steroids.
Fertil Steril. 1971 Nov;22(11):735-40.
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