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HGH + IGF-1 + Insulin - A basic guide

There are volumes of information and studies available about using HGH, IGF-1, and Insulin, but for the most part coming up with a good cycle including all of these is a tedious process and requires more reading than most people wish to do or have the time to do. The following is meant to a quick and simple reference to what a cycle including all three might look like and a brief description of the action of each component.

Weeks 1- (20-30) - HGH - On 5/ off 2
2 - 2.5 IU's first thing in the morning
2 - 2.5 IU's early afternoon
injected Sub-C into abdomen, obliques, fronts of the thighs, upper triceps

Weeks 1-5, 11-15, (21-25) - Long R3 IGF-1 - Every day
60mcg's intramuscular post work out on workout days,
first thing in the morning on non workout days

Weeks 6-10, 16-20, (26-30) - Humalog - Workout days only
8IU's immediately post workout, intramuscular
*** alternatively, you could run the Humalog on 1-5, 11-15, (21-25) with your LR3 if you prefer, depending on your cycle goal***

Immediately after Humalog injection - do the following
Injection + 5 minutes - drink shake with 10g glutamine / 10g creatine / 55g dextrose
Injection + 15 minutes - drink shake with 80g of whey protein in water
Injection + 60 - 75 minutes - eat a protein / carb meal with 40-50g of protein, 40-50g of carbs, NO FATS
Avoid fats for 2-3 hours for Humalog IM, 3-4 hours for Humalog sub-q, 4-5 hours for Humulin-R.
**keep some glucose tablets or other simple carbs on hand for the active window of your insulin. Hypo symptoms can and will hit hard and fast and you will have little time to react. This is the main danger of insulin use. Be ready.***

T3 - 12.5mcg per day (or 12.5mcgs ->100-150mcgs ->12.5mcgs if used for fat loss instead of protein synthesis assist)


HGH should ideally be used for 20-30 week cycles (or longer). The dosage should be between 2-3IU per day if you are using GH primarily for fat loss, 4-5 IU's a day for both fat loss and muscle growth, and approximately 1.0 - 2.0 IU's a day for females. It is best to split your injections 1/2 first thing in the morning, 1/2 early afternoon if your dose is above 2.0IU's per day. Your pituitary will naturally produce about 10 pulses of GH per day. Each injection you take will create a negative feedback loop that will suppress these pulses for about 4 hours. By taking your injections first thing in the morning and early afternoon you will still allow your body to release its biggest pulse, which normally occurs shortly after going to sleep at night.

When starting out with your HGH cycle, for most people it is wise to begin you dose at 1.5 -  2.0IU per day for the first couple of weeks, and then begin increasing your dose by 0.5 to 1.0 units every week or two until you reach your desired level. While it isn't an absolute necessity to do this, if you are sensitive to the type of sides HGH present you will often times avoid these sides of joint pain/swelling, and bloating/water retention by slowly acclimating to your ultimate 4-5 IU's /day goal.

You should use an U100 insulin syringe for injecting HGH, and inject it Sub-C into your abdomen, obliques, top of thighs, triceps. Rotate injection sites. HGH can have a small localized fat loss benefit, so keep this in mind when choosing your injection sites.

When HGH makes it pass through the liver, a release of IGF-1 is a result. IGF-1 appears to be the key player in muscle growth. It stimulates both the differentiation and proliferation of myoblast. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues. While HGH will cause an increase in your IGF-1 level over the course of a few months, HGH has a cumulative effect, so the addition of IGF-1 will greatly speed up the time to results.

There are two types of IGF-1 that will typically be used by bodybuilders. One is bio-identical HuIGF-1, a 70 amino acid string. The other is Long R3 IGF-1, which is an 83 amino acid analog of human IGF-I comprising the complete human IGF-I sequence with the substitution of an Arg for the Glu at position 3 (hence R3), and a 13 amino acid extension peptide at the N-terminus (hence the long). Which of these you use depends on your goal.

HuIGF-1 is very short lived in the body (half life of probably around 10 minutes). This type of IGF-1 is very useful if you are seeking local site growth. Since it is so short lived, little of the IGF-1 makes it to other tissues and IGF-1 receptors in the body. The way to inject this is immediately post work out into the muscle that you wish to have local site growth. Use a U100 insulin syringe, and inject 80mcg's bilaterally into the desired muscle immediately post workout. For this type of IGF-1, I would use it workout days only or if desired you could inject on non-workout days first thing in the morning into a muscle group worked the previous day.

For Long R3 IGF-1, it isn't as critical that you inject into a local site as long R3 has a active window of many hours, and is designed specifically to resist being bound. Since it is common to reconstitute this type of IGF-1 with Benzyl Alcohol, Acetic Acid, or Hydrochloric Acid I would still recommend that you inject intra-muscular. It can and probably will leave a nice red irritated spot if you inject Sub-C. I still inject into a muscle just worked to take advantage of increased IGF-1 receptors, but because of the long activity window of this type of IGF-1 any muscle will work well and give you good results,. I would suggest that you inject between 40-80mcg's per day everyday immediately post workout on workout days, and first thing in the morning on non-workout days.

Use a U-100 insulin syringe with 1/2" needle to inject IGF-1 intramuscular (bilaterally for HuIGF-1, bilaterally optional for Long R3)

Working out causes us to end up in a catabolic state. It is important to back in a positive nitrogen balance as soon as possible. When not using insulin, we drink some dextrose with our protein to cause an insulin spike immediately post workout to help shuttle the protein and sugars to the muscles.

Insulin is very good at shuttling nutrients to the muscles, and works in a very complimentary manner with GH in the types of things that they shuttle. Also, HGH can cause an amount of insulin resistance, so adding some insulin to your cycle will offset any potential resistance that might occur during your HGH cycle.

For the purposes that we are using insulin, a dosage of 4-10IU's is adequate and should be used immediately post workout. I personally prefer using Humalog intramuscular as it will cause a rapid spike and clear out of your system quickly. You can use it sub-q or use Humulin-R instead, but each of these will result in a longer active window, thus a longer time to avoid eating any fats and watching your carb intake. Any fats or over abundance of carbs will end up being stored as fat during insulin's active window. The approximate windows are:
Intramuscular  ---- 2-3 hours
subcutaneous  --- 3-4 hours
Humulin R
Intramuscular ---- 3-4 hours
subcutaneous  --- 4-5 hours

Use a U-100 insulin syringe with 1/2" needle to inject IM immediately post workout. Alternatively, you can inject Sub-C if desired or if you wish a longer active window for some reason. Begin with a dose of 2IU's or so, and increase the dose each workout day until you reach your 8IU's.

If for some reason you wish to avoid insulin, I would still suggest that immediately post workout you spike you own endogenous insulin by drinking 80 grams of dextrose / 40 grams of whey isolate protein. While this certainly won't do the work of 8-10 IU's of Humalog, it will most certainly assist getting your muscle back in a nitrogen positive environment in a short amount of time.
HGH can have a slight inhibitory effect on your thyroid. For most people this is minimal and does not require any additional thyroid be taken, but if you wish to augment protein synthesis as well as give yourself a slight boost in thyroid without shutting down your own production, you can add 12.5mcg of T3 daily to your HGH, IGF-1, Insulin cycle. This will aid both in bulking and cutting.

If you add this, you should also consider taking some thyroid support supplements such as t-100x, bladderwrack, coleus forskolin. You should check and make sure your intake of trace minerals (selenium, zinc, copper) is sufficient to aid in the conversion of T4 to T3.

If you are going to take more than 12.5 mcg of T3, you will need to cycle the dose both up and down to avoid a rebound effect when going off cycle, but for our use with an HGH cycle and use in assisting with protein synthesis, 12.5mcg will be sufficient. If you wish to use T3 in conjunction with the above for heavy cutting, begin with 12.5mcgs, ramp up to 100-150mcgs, then slowly back down tapering back to 12.5 mcgs for a time before discontinuing use. This will minimize the chance for rebound while your own thyroid gets back in gear.

Well, I think that about covers it. add a cycle or two of your favorite testosterone and you have a great combination for bulking or cutting. 


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